All About AMPK Activators
AMPK is deemed as the regulator that maintains cellular energy homeostasis that is the foundation for proper functioning of the body. In mammals, AMPK regulates the energy balance both on whole body level via response to the hormones and the brain and on cellular levels by way of sensing ATP/AMP and ATP/ADP ratio levels.
ATP is actually the most significant energy molecule present in the body. Simply put, this is where cellular function all begins. ATP breaks down into ADP that has less potential for energy since the cells are using energy. ADP is broken down to AMP containing the least energy potential among all 3. This is where AMPK steps in, it is sensing the relative ratios of ATP/ADP/AMP and telling the body if it needs more ADP so by that, it maintains proper functioning.
AMPK acts on various processes through different mechanisms. This makes sense since AMPK is the master regulator of all functioning cells. The effect that AMPK activation in the body depend on the complicated balance of factors and the signaling pathways. Even so, there are some accepted benefits of increased AMPK activation including:
Anti aging – as we age, comes along with the gradual decline of AMPK activation. As a matter of fact, many experts believe that one factor that contributes to aging is AMPK. It is promoting cellular renewal and also, the production of new mitochondria.
Anti inflammation – inflammation decreases the level of AMPK activation in the body but what’s interesting is that, AMPK is used as well to decrease inflammation.
Anti diabetic – as a matter of fact, AMPK is slowly becoming well understood in relation to its role in diabetes treatment primarily because of its capability to enhance insulin sensitivity.
There are so many herbal products/constituents as well as nutritional products that have been proven to be an effective AMPK activator and some of it include:
Number 1. AICAR – this is the analog of AMP which is needed in cellular use and storage similar to ATP. AICAR has been studied and discovered to directly affect AMPKs activity that helps it to improve muscle performance all because it’s the analog of AMP.
Number 2. ALA – this is an abbreviation for Alpha Lipoic Acid that is a powerful AMPK activator and at the same time, popular for its effective antioxidant content. It’s been shown to boost the sensitivity of insulin in the body and also, carries anti obesity effects.
Number 3. Green tea extract – this helps in activating upstream kinase which then helps in activating AMPK.
Number 4. Berberine – with AMPK activation, berberine was known to bring the same anti diabetic effect as metformin.